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White Powder 99% USP Grade Active Pharmaceutical Ingredient Estradiol Oestradiol CAS 50-28-2

Categories Active Pharmaceutical Ingredient
Brand Name: VANZ
Model Number: 50-28-2
Place of Origin: China
MOQ: 100g
Price: 1-10 USD per gram
Packaging Details: 10g,100g, 1kg alunimum foil bags or 25kg drum
Appearance: white powder
Synonyms: Estra-1,3,5(10)-triene-3,17β-diol; 17β-Estradiol
CAS: 50-28-2
Purity: 99%min
MF: C18H24O2
MW: 272.38
Company Info.
Wuhan Vanz Pharm Inc.
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    White Powder 99% USP Grade Active Pharmaceutical Ingredient Estradiol Oestradiol CAS 50-28-2

    White Powder 99% USP Grade Estradiol Oestradiol API CAS: 50-28-2


    Estradiol (E2), also spelled oestradiol, is a steroid, an estrogen, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues such as the breasts, uterus, and vagina during puberty, adulthood, and pregnancy, but it also has important effects in many other tissues including bone, fat, skin, liver, and the brain. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species


    Basic information


    NameEstradiol
    CAS50-28-2
    Appearancewhite powder
    MFC18H24O2
    MW272.38
    Purity99%min

    Function

    1. Sexual development

    2. Female reproduction

    3. Male reproduction

    4. Bone

    5. Brain

    6. Gynecological cancers


    Certificate of Analysis
    Product NameEstradiolBatch Size10KG
    Manufacturing Date2016.09.08Batch No.20160908
    Expiry Date2018.09.07Report Date2016.09.08
    Reference StandardUSP 36Packing
    TESTACCEPTANCE CRITERIONSRESULTS
    IdentificationInfrared AbsorptionPositive
    CharacteristicsWhite or creamy white, crystalline powderconform
    Melting point173 ~ 179℃177~ 179℃
    Specific rotation﹢76°~﹢83°﹢78.5°
    Water≤3.5%pass
    Assay97 .0~ 103.0%99.07%
    Loss on drying≤0.5%0.16%
    Related substancestotal impurities ≤1.0%Pass
    Residual solventsethanol ≤0.5%Pass
    Particle sizePass
    ConclusionThis batch complies with USP 326
    SupervisorAnalyst

    Biological activity


    Estradiol acts primarily as an agonist of the estrogen receptor (ER), a nuclear steroid hormone receptor. There are two subtypes of the ER, ERα and ERβ, and estradiol potently binds to and activates both of these receptors. The result of ER activation is a modulation of gene transcription and expression in ER-expressing cells, which is the predominant mechanism by which estradiol mediates its biological effects in the body.

    Estradiol also acts as an agonist of membrane estrogen receptors (mERs), such as GPER (GPR30), a recently discovered non-nuclear receptor for estradiol, via which it can mediate a variety of rapid, non-genomic effects.Unlike the case of the ER, GPER appears to be selective for estradiol, and shows very low affinities for other endogenous estrogens, such as estrone and estriol.Additional mERs besides GPER include ER-X, ERx, and Gq-mER.


    In the E2 classical pathway or estrogen classical pathway, estradiol enters the cytoplasm, where it causes dissociation of heat-shock protein (HSP). Estradiol then binds to HSP and can homodimerise (form structures of two HSP and two estradiol molecules) and then bind to specific domains on the nucleus (estrogen response element, ERE), allowing for gene transcription which can take place over hours and days.


    Estradiol is about 10 times as potent as estrone and about 80 times as potent as estriol in its estrogenic effect.



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